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Curriculum vitae
20 ans d'expérience dans le secteur pharmaceutique
Pour votre projet pharmaceutique / médical spécifique (développement, expertise, dossier, formation ou autre) vous êtes à la recherche d'un consultant expérimenté au profil particulier.
Vous trouverez ci-dessous un résumé de mon parcours professionnel et de mes travaux scientifiques passés.
Expériences professionnelles
- Aujourd’hui,
Consultant freelance en développement pharmaceutique et dispositifs médicaux,
Président cofondateur d’eXinov, start-up développant des dispositifs médicaux,
Cofondateur de Nepios Pharma, pour le développement de produits pédiatriques - Horama
- Santen Pharmaceutical
- Novagali Pharma
- Université de Genève
- Servier
Formations spécialisées
- Les BPF
- La norme ISO 13485
- Le pharmacien responsable
- Transfert de production
- Les 5S
- Audit qualité
- Nanotechnologies
Formation de base
- Pharmacien de la faculté de pharmacie de Châtenay-Malabry (Paris XI)
- DEA de pharmacotechnie et Biopharmacie faculté de pharmacie de Châtenay-Malabry (Paris XI)
- Doctorat d’Etat en sciences pharmaceutiques de l’université de Genève
Travaux
Articles scientifiques (13)
- Frédéric Lallemand, M. Schmitt, J.-L. Bourges, R. Gurny, S. Benita, J.-S. Garrigue, Cyclosporine A delivery to the eye: review of all approaches for the past 15 years, European J Pharm Biopharm, 2016
- Y. Hamdi, Frédéric Lallemand, S. Benita, Drug-loaded Nanocarriers for Back-of-the-Eye Diseases- Formulation Limitations, Journal of Drug Delivery Science and Technology, 30(2015) 331-341
- Frédéric Lallemand, P. Daull, JS. Garrigue: “Development of a Cationic Nanoemulsion Platform (Novasorb®) for Ocular Delivery” Book Chapter in Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Published by Springer José das Neves (Editor) and Bruno Sarmento (Editor), 2013
- P. Daull, Frédéric Lallemand and J-S. Garrigue, Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery, Journal of Pharmacy and Pharmacology, 2013 May 26
- Daull P, Lallemand Frédéric, Philips B, Lambert G, Buggage R, Garrigue JS. Distribution of Cyclosporine A in Ocular Tissues After Topical Administration of Cyclosporine A Cationic Emulsions to Pigmented Rabbits. Cornea. 2012 Sep 27
- Frédéric Lallemand, P. Daull, S. Benita, R. Buggage, J-S Garrigue, Review article: Successfully improving ocular drug delivery using the cationic nanoemulsion Novasorb®, Journal of Drug Delivery February 2012
- Frédéric Lallemand, E. Varesio, G. Hopfgartner, O. Felt-Baeyens, R. Gurny, Biological and chemical conversion mechanisms of a water-soluble prodrug of cyclosporine A, Eur J Pharm Biopharm. 2007 Sep;67(2):555-61
- J.L. Bourges, Frédéric Lallemand, E. Agla, K. Besseghir, J.M. Dumont, D. BenEzra, R. Gurny, F. Behar- Cohen. Evaluation of a topical cyclosporine A prodrug on corneal graft rejection in rats. Mol Vis. 2006 Dec 2;12:1461-6
- S. Veltkamp, B. Thijssen, JS. Garrigue, G. Lambert, Frédéric Lallemand, F. Binlich, A. Huitema, B. Nuijen,A. Nol, JH. Beijnenand J. Schellens, A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer, British Journal of Cancer (2006), 1-6
- Frédéric Lallemand, O. Felt-Baeyens, S. Rudaz, A. R. Hamel, F. Hubler, R. Wenger, M. Mutter, K. Besseghir, R. Gurny, Conversion of Cyclosporine A prodrugs in human tears vs rabbits tears, Eur J Pharm Biopharm. 2005 Jan;59(1):51-6
- Frédéric Lallemand, P. Perrottet, O. Felt-Baeyens, W. Kloeti, F. Philippoz, J. Marfurt, K. Besseghir, R. Gurny, A water-soluble prodrug of cyclosporine A for ocular application: a stability study, Eur J Pharm Sci., 26 (2005) 124-9
- Frédéric Lallemand, P. Furrer, M. Gex-Fabry, O. Felt-Baeyens, J.-M. Dumont, K. Besseghir, R. Gurny, A novel water-soluble cyclosporine A prodrug : ocular tolerance and in vivo kinetics, Int J Pharm.; 295 (2005) 7-14
- Frédéric Lallemand, O. Felt-Baeyens, K. Besseghir, F. Behar-Cohen, R. Gurny, Cyclosporine A delivery to the eye: A pharmaceutical challenge, Eur. J. Pharm. Biopharm., 56 (2003) 307-318.
Présentations orales (12)
- Frédéric Lallemand, Challenges in the up-scaling manufacturing of Cationic Nanoemulsions, MIXiii-Biomed, Tel Aviv, Israel, May 15-17, 2018.
- Frédéric Lallemand, Cationic emulsions in ophthalmology: from bench to bedside, Ocular Drug Delivery – State-of-the-Art and New Concepts, APV e. V. June 20-21, 2016, Berlin, Germany
- Frédéric Lallemand, Cationic nano-emulsions: a versatile platform for topical ocular delivery, PBP World Meeting, April 4-7 2016, Glasgow, UK
- Frédéric Lallemand, La technologie Novasorb et ses applications : innovation dans le développement des gouttes oculaires, Journées de Réflexions Ophtalmologiques, 12-14 mai 2015, Paris, France.
- Frédéric Lallemand, When nanotechnology meets ophthalmology, White Nights International Ophthalmology Congress 26-30 May, 2014 St. Petersburg, Russia.
- Frédéric Lallemand, Rationale for use of cationic emulsions in ophthalmology: from bench to patients, 8th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT), March 2013, Paris, France.
- J. Garrigue, B. Philips, P. Daull, Frédéric Lallemand, Oily-based Carriers for intravitreal sustained Drug delivery, 8th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT), Roma, Italy, December 3-6, 2009.
- Frédéric Lallemand, Pre-clinical development of a new treatment for VKC, XIV Afro-asian congress of ophthalmology, Marrakesh, Morocco, June 24th, 2007
- Frédéric Lallemand, A new paradigm in ophthalmology: cationic emulsion, Bio-innovation day, Geneva, Switzerland, March 5th, 2006.
- Frédéric Lallemand, New formulations for topical applications of cyclosporine A, Ghent, Belgium, June 8-11, 2005
- Frédéric Lallemand, F. Behar-Cohen, O. Felt-Baeyens, S. Rudaz, P. Furrer, K. Besseghir, J.-M. Dumont, R. Gurny, Development of UNIL088, a cyclosporine A prodrug for topical delivery to the eye, 5th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT), Monte-Carlo, Monaco, March 11-14, 2004.
- Frédéric Lallemand, O. Felt-Baeyens, R. Gurny, Ocular Delivery of cyclosporine A: a pharmaceutical challenge. 15th International Congress of Eye Research (ICER), Geneva, Switzerland, October 6-10, 2002.
Posters (5)
- Le Meur G., Lebranchu P., Deltour JB, Billaud F, Delaunay N, Lallemand Frédéric, Marconi S, Weber M; Phase I/II study to evaluate the safety and biological activity of HORA-PDE6B in patients with PDE6B retinitis pigmentosa ARVO, Honolulu, USA, April 2018.
- Frédéric Lallemand, G. Lambert, L. Rabinovich, P. Daull, J-S Garrigue, Distribution of cyclosporine A in ocular tissues after topical administration of cyclosporine A-cationic emulsion to pigmented rabbits. The association for research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, May 1-5, 2011.
- F. Behar-Cohen, J.-L. Bourges, E. Agla, F. Valamanesh, Frédéric Lallemand, R. Gurny, J.-M. Dumont, K. Besseghir, Prevention of corneal graft rejection by eyedrop instillation of UNIL088, a hydrosoluble prodrug of cyclosporin A, The association for research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, April 25-29, 2004.
- P. Furrer, G.M. Paladino, Frédéric Lallemand, J.M. Mayer, R. Gurny, Wound healing follow-up by confocal microscopy. 4th International Symposium on Ocular Pharmacology and Pharmaceutics (ISOPP), Seville, Spain, February 28 - March 3, 2002.
- M.G. Mazzone, G.M. Paladino, C. Marino, F. Trombetta, P. Furrer, Frédéric Lallemand, R. Gurny, V. Enea, Biopolymer formulations in a wound healing model. XV International Congress of Eye Research (ICER), Geneva, Switzerland, October 6-10, 2002.
Brevets d'invention (12)
- Ophthalmic micellar compositions with enhanced stability,
EP2077105 - Micellar compositions with ophthalmic applications,
EP2077104 - Compositions comprising corticosteroid prodrug such as dexamethasone palmitate for the treatment of eye disorders,
WO2009071594 - Composition comprising at least one nucleosidic moiety as a therapeutic agent and CKC,
WO2009063081 - Oil-in-water emulsion comprising NSAIDS and quaternary ammonium halides,
WO2009007409 - Process for manufacturing ophthalmic oil-in-water emulsions,
WO2008074885 - Compositions containing quaternary ammonium compounds (BAK),
EP1891939 - Compositions containing quaternary ammonium compounds (CKC),
WO2008012367 - Cationic oil-in-water emulsions containing prostaglandins and uses thereof,
EP2403477 - Anionic oil-in-water emulsions containing prostaglandins and uses thereof,
EP2403478 - Bioresorbable tamponade for retinal detachment,
EP2501361 - Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions,
EP2389939